About

The Hartmann Lab is located at McLean Hospital in Belmont, MA, and is affiliated with the Department of Psychiatry at Harvard Medical School. We are dedicated to exploring the molecular, cellular, and neurocircuit-specific changes that shape an individual’s trajectory towards susceptibility or resilience to stress-related mental disorders. Our research employs a combination of mouse models, machine learning based behavioral analysis, single-cell transcriptomics, and viral vectors to gain deeper insights into the specific cell types and polygenic architecture involved in stress-related psychiatric disorders including major depressive disorder (MDD) and post-traumatic stress disorder (PTSD).

Another crucial aspect of our research centers around the crosstalk between neuronal stress circuits and the immune system with a specific focus on the impact of chronic stress on neuroinflammation and neurodegeneration. Our multidisciplinary approach encompasses primary cell cultures, genetic and transgenic techniques in mice, and analysis of human postmortem brain tissue. By integrating clinical and preclinical data, our goal is to unravel the complex interplay between stress and immune function in psychiatric and neurodegenerative disorders.

Through our comprehensive investigations, we strive to advance knowledge and identify potential therapeutic interventions for stress-related psychiatric disorders and neurodegenerative diseases.

At the Hartmann Lab, we believe that a diverse and inclusive environment is key to driving our research forward. We are committed to fostering an inclusive culture that respects and embraces the diversity of thoughts, experiences, and backgrounds. We aim to create an environment where every member of our team feels valued, respected, and able to contribute to their fullest potential.